Research & Clinical Studies  


People who regularly take supplements or medication develop a phenomenon called "tolerance". Physical tolerance occurs when an organism builds up a resistance to the effects of a substance after repeated exposure. Decreased quantity of the substance reaching the site it affects. This is usually caused by an increase in induction of the enzymes required for degradation of the supplement. In other words, tolerance is a reduced response to repeated administration of the same dose or increase in the dose is required to produce the same magnitude of response. Once we begin to take supplement on a regular basis the dose response goes down - the same dose of medication produces less effect than it used to. Saying that the dose response to medication goes down is exactly the same as saying that medication tolerance goes up (and vice versa). Dose response and tolerance are mirror images of each other. As long as a steady use of medication is maintained, tolerance will tend to increase and dose response will tend to drop. In order to avoid this and get the expected result switching the products to those with different content or adding new ingredients is required.

* Visualization purpose only, actual results depend on diet and exercise


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Milk Thistle Extract
Milk Thistle
helps to protect the liver against toxicity from acetaminophen (Tylenol), alcohol and other drugs. In Europe, milk thistle is reportedly administered to patients when they are given medications known to cause liver problems. [source]
Saffron Extract Appetite Suppresant
Saffron Extract
are purported to curb appetite and reduce cravings. Some proponents suggest that saffron can help increase brain levels of serotonin (a chemical known to regulate mood) and, in turn, help prevent compulsive overeating and the associated weight gain. [source 1]   [source 2]


Milk Thistle Extract
is a powerful anti-inflammatory herb. It has been indicated for arthritis, fevers, headaches, toothaches, coughs, bronchitis, osteoarthritis, rheumatoid arthritis, to ease tendonitis and lower cholesterol and blood-pressure.
Hydrangea Root
Hydrangea root
acts as a solvent and is thought to smooth the jagged edges of kidney stones. Hydrangea root also appears to help the body properly use calcium, an action that may be helpful for discouraging kidney stones from forming in the first place. [source]


Green Coffee Bean Extract
Green Coffee Bean
beneficial to those trying to lose weight, according to a 2011 research review published in Gastroenterology Research and Practice focused on the available clinical trials testing green coffee extract's efficacy as a weight loss supplement. [source]
Hydrangea Extract
Raspberry Ketone
is a chemical from red raspberries that is thought to help for weight loss. Some research in animals or in test tubes shows that it might increase some measures of metabolism. It might also affect a hormone in the body called adiponectin. [source 1]   [source 2]


Maqui Berry
Maqui Berry
studies indicate that anthocyanins may possess anti-cancer properties, fight obesity and enhance heart health. It's also known as a natural remedy for several health conditions, including arthritis, high cholesterol, fight obesity and enhance heart health.
[source 1]   [source 2]
Coenzyme Q10 (CoQ10) is a nutrient that occurs naturally in the body. CoQ10 is also in many foods we eat. CoQ10 acts as an antioxidant, which protects cells from damage and plays an important part in the metabolism. [source 1]   [source 2]   [source 3]


African Mango Irvingia Gabonensis
Irvingia Gabonensis
study result suggested that the it's soluble fiber content helps to slow digestion and absorption of dietary sugar. African mango extract fiber forces the body to convert more cholesterol into bile acids and thus helping with cholesterol levels. [source 1]   [source 2]
Lychee Extract
Lychee Extract
is an excellent source of vitamin C. A compound extracted from lychee called Oligonol(R) have benefits for skin through improving the blood flow to the sub dermal skin layer and protecting it from damage. [source]


Green Tea Extract
Green Tea Extract
 is made from the leaves of the Camellia sinensis L plant, which is rich in polyphenol catechins and caffeine. There is increasing interest in the potential role of green tea extract (GTE) in fat metabolism and its influence on health and exercise performance. [source]
is a popular natural remedy said to offer a broad range of health benefits. Found naturally in the skin of grapes, resveratrol is widely available in supplement form.
[source 1]   [source 2]


Clinical References:

  1. Haskell CF, Kennedy DO, Wesnes KA, Milne AL, Scholey AB. A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guarana in humans.J Psychopharmacol. 2007 Jan;21(1):65-70. Epub 2006 Mar 13.
  2. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol. 2002 Sep;40(9):1243-55.
  3. Graham TE. Caffeine and exercise: metabolism, endurance and performance.. Sports Med. 2001;31(11):785-807.
  4. Erica Goldstein, Patrick L Jacobs, Michael Whitehurst, Tina Penhollow and Jose Antonio. Caffeine enhances upper body strength in resistance-trained women. Journal of the International Society of Sports Nutrition 2010, 7:18
  5. Tomonori Nagao, Tadashi Hase and Ichiro Tokimitsu. A Green Tea Extract High in Catechins Reduces Body Fat and Cardiovascular Risks in Humans. Obesity (2007) 15, 1473ñ1483; doi: 10.1038/oby.2007.176
  6. Morimoto C, Satoh Y, Hara M, Inoue S, Tsujita T, Okuda H. Anti-obese action of raspberry ketone. Life Sci. 2005 May 27;77(2):194-204. Epub 2005 Feb 25.
  7. Ahuja KD, Robertson IK, Geraghty DP, Ball MJ. The effect of 4-week chilli supplementation on metabolic and arterial function in humans. Eur J Clin Nutr. 2007;61(3):326-33.
  8. Teruo Kawada, Koh-Ichiro Hagihara and Kazuo Iwai. Effects of Capsaicin on Lipid Metabolism in Rats Fed a High Fat Diet J. Nutr. 116: 1272-1278, 1986.



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